Exposure to the Natural Compound Climacostol Induces Cell Damage and Oxidative Stress in the Fruit Fly <i>Drosophila melanogaster</i>

Exposure to the Natural Compound Climacostol Induces Cell Damage and Oxidative Stress in the Fruit Fly <i>Drosophila melanogaster</i>

The ciliate <i>Climacostomum virens</i> produces the metabolite climacostol that displays antimicrobial activity and cytotoxicity on human and rodent tumor cells. Given its potential as a backbone in pharmacological studies, we used the fruit fly <i>Drosophila melanogaster</i>...

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Bibliographic Details
Main Authors: Elisabetta Catalani, Kashi Brunetti, Simona Del Quondam, Silvia Bongiorni, Simona Picchietti, Anna Maria Fausto, Gabriele Lupidi, Enrico Marcantoni, Cristiana Perrotta, Gabriele Achille, Federico Buonanno, Claudio Ortenzi, Davide Cervia
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Toxics
Subjects:
secondary metabolite
<i>Drosophila melanogaster</i>
larvae development
cell damage
redox homeostasis
gastrointestinal tract
Online Access:https://www.mdpi.com/2305-6304/12/2/102

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https://www.mdpi.com/2305-6304/12/2/102

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