Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis

Abstract Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To i...

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Bibliographic Details
Main Authors: Toyofumi Hirakawa, Fusanori Yotsumoto, Naoto Shirasu, Chihiro Kiyoshima, Daichi Urushiyama, Kenichi Yoshikawa, Kohei Miyata, Masamitsu Kurakazu, Kaori Azuma Koga, Mikiko Aoki, Kazuki Nabeshima, Kaori S. Koga, Yutaka Osuga, Hiroaki Komatsu, Fuminori Taniguchi, Tasuku Harada, Shin’ichiro Yasunaga, Shingo Miyamoto
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-11891-5