Polydeoxyribonucleotide Exerts Protective Effect Against CCl<sub>4</sub>-Induced Acute Liver Injury Through Inactivation of NF-κB/MAPK Signaling Pathway in Mice

Polydeoxyribonucleotide Exerts Protective Effect Against CCl<sub>4</sub>-Induced Acute Liver Injury Through Inactivation of NF-κB/MAPK Signaling Pathway in Mice

Acute liver injury (ALI) causes life-threatening clinical problem, and its underlying etiology includes inflammation and apoptosis. An adenosine A<sub>2A</sub> receptor agonist, polydeoxyribonucleotide (PDRN), exhibits anti-inflammatory and anti-apoptotic effects by inhibiting the secret...

Full description

Bibliographic Details
Main Authors: Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jin Hee Han, Seunghwan Lee, Ha Il Kim, Hyun Phil Shin, Jung Won Jeon
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
acute liver injury
polydeoxyribonucleotide
nuclear factor-kappa B
mitogen-activated protein kinase
inflammation
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/21/7894

Internet

https://www.mdpi.com/1422-0067/21/21/7894

Similar Items