Modeling double strand break susceptibility to interrogate structural variation in cancer

Modeling double strand break susceptibility to interrogate structural variation in cancer

Abstract Background Structural variants (SVs) are known to play important roles in a variety of cancers, but their origins and functional consequences are still poorly understood. Many SVs are thought to emerge from errors in the repair processes following DNA double strand breaks (DSBs). Results We...

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Bibliographic Details
Main Authors: Tracy J. Ballinger, Britta A. M. Bouwman, Reza Mirzazadeh, Silvano Garnerone, Nicola Crosetto, Colin A. Semple
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Biology
Subjects:
Double strand break
Cancer
Structural variation
Chromatin
Modeling
Online Access:http://link.springer.com/article/10.1186/s13059-019-1635-1

Internet

http://link.springer.com/article/10.1186/s13059-019-1635-1

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