Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques

Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques

ABSTRACT Alternative delivery routes of the current Mycobacterium tuberculosis (Mtb) vaccine, intradermally (ID) delivered BCG, may provide better protection against tuberculosis, and be more easily administered. Here, we use rhesus macaques to compare the airway immunogenicity of BCG delivered via...

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Bibliographic Details
Main Authors: Stella G. Hoft, Keith D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Daniel F. Hoft, Richard Herbert, Daniel L. Barber
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
BCG
CD4 T cells
immunization
immunology
lung defense
rhesus macaques
Online Access:https://journals.asm.org/doi/10.1128/mbio.00220-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00220-23

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