RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A

RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A

Hemophilia A is a hemorrhagic disease due to congenital deficiencies of coagulation factor VIII (FVIII). Studies show that hemophilia patients with anticoagulant deficiency present less severe hemorrhagic phenotypes. We aimed to find a new therapeutic option for hemophilia patients by RNA interferen...

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Bibliographic Details
Main Authors: Wen-yi Lin, Ruiqi Zhu, Zhen Zhang, Xuan Lu, Huafang Wang, Wenjuan He, Yu Hu, Liang Tang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
hemostasis
hemophilia
RNA interference
heparin cofactor II
thrombin
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000937

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http://www.sciencedirect.com/science/article/pii/S2162253121000937

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