FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination

FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination

Summary: Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability. To evaluate this, we generated stable cell lines expressing P...

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Bibliographic Details
Main Authors: Wendy Leung, Ryan M. Baxley, Emma Traband, Ya-Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall S. Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George-Lucian Moldovan, Naoko Shima, Anja-Katrin Bielinsky
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015358

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http://www.sciencedirect.com/science/article/pii/S2211124723015358

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