Mad2 Induced Aneuploidy Contributes to <i>Eml4-Alk</i> Driven Lung Cancer by Generating an Immunosuppressive Environment

Mad2 Induced Aneuploidy Contributes to <i>Eml4-Alk</i> Driven Lung Cancer by Generating an Immunosuppressive Environment

Aneuploidy, an imbalance number of chromosomes, is frequently observed in lung cancer and inversely correlates with patient survival. Paradoxically, an aneuploid karyotype has detrimental consequences on cellular fitness, and it has been proposed that aneuploid cells, at least in vitro, generate sig...

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Bibliographic Details
Main Authors: Kristina Alikhanyan, Yuanyuan Chen, Kalman Somogyi, Simone Kraut, Rocio Sotillo
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
lung cancer
aneuploidy
tumor microenvironment
immune suppression
mouse models
Online Access:https://www.mdpi.com/2072-6694/13/23/6027

Internet

https://www.mdpi.com/2072-6694/13/23/6027

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