Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B). Current models only partially recapitulate key disease features, and pathophysiology is poorly understood. Through dev...

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Bibliographic Details
Main Authors: Matthew D Keefe, Haille E Soderholm, Hung-Yu Shih, Tamara J Stevenson, Kathryn A Glaittli, D Miranda Bowles, Erika Scholl, Samuel Colby, Samer Merchant, Edward W Hsu, Joshua L Bonkowsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
leukodystrophy
induced stress response
vanishing white matter disease
EIF2B5
MRI
myelin
Online Access:https://elifesciences.org/articles/56319

Internet

https://elifesciences.org/articles/56319

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