Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolate resistance...

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Main Authors: Richard J Pearce, Hirva Pota, Marie-Solange B Evehe, El-Hadj Bâ, Ghyslain Mombo-Ngoma, Allen L Malisa, Rosalynn Ord, Walter Inojosa, Alexandre Matondo, Diadier A Diallo, Wilfred Mbacham, Ingrid V van den Broek, Todd D Swarthout, Asefaw Getachew, Seyoum Dejene, Martin P Grobusch, Fanta Njie, Samuel Dunyo, Margaret Kweku, Seth Owusu-Agyei, Daniel Chandramohan, Maryline Bonnet, Jean-Paul Guthmann, Sian Clarke, Karen I Barnes, Elizabeth Streat, Stark T Katokele, Petrina Uusiku, Chris O Agboghoroma, Olufunmilayo Y Elegba, Badara Cissé, Ishraga E A-Elbasit, Hayder A Giha, S Patrick Kachur, Caroline Lynch, John B Rwakimari, Pascalina Chanda, Moonga Hawela, Brian Sharp, Inbarani Naidoo, Cally Roper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC2661256?pdf=render

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http://europepmc.org/articles/PMC2661256?pdf=render

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