AcT Trial: Protocol for a Pragmatic Registry‐Linked Randomized Clinical Trial

AcT Trial: Protocol for a Pragmatic Registry‐Linked Randomized Clinical Trial

Background Intravenous thrombolysis with alteplase is widely used in patients with acute ischemic stroke presenting early after symptom onset. Recent phase II trials have suggested that intravenous tenecteplase may be safer and associated with higher early reperfusion rates as compared with alteplas...

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Main Authors: Tolulope Sajobi, Nishita Singh, Mohammed A. Almekhlafi, Brian Buck, Ayoola Ademola, Shelagh B. Coutts, Yan Deschaintre, Houman Khosravani, Ramana Appireddy, Francois Moreau, Stephen Phillips, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, J.J. Shankar, Heather Williams, Thalia S. Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhoude, Gary Hunter, Arshia Sehgal, Qiao Zhang, Craig Doram, Michael D. Hill, Michel Shamy, Carol Kenney, Richard H. Swartz, Bijoy K. Menon
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Stroke: Vascular and Interventional Neurology
Subjects:
acute stroke
clinical trials
consent
emergency
ethics
pragmatic
Online Access:https://www.ahajournals.org/doi/10.1161/SVIN.122.000447

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https://www.ahajournals.org/doi/10.1161/SVIN.122.000447

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