Features of CRISPR-Cas Regulation Key to Highly Efficient and Temporally-Specific crRNA Production

Features of CRISPR-Cas Regulation Key to Highly Efficient and Temporally-Specific crRNA Production

Bacterial immune systems, such as CRISPR-Cas or restriction-modification (R-M) systems, affect bacterial pathogenicity and antibiotic resistance by modulating horizontal gene flow. A model system for CRISPR-Cas regulation, the Type I-E system from Escherichia coli, is silent under standard laborator...

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Bibliographic Details
Main Authors: Andjela Rodic, Bojana Blagojevic, Magdalena Djordjevic, Konstantin Severinov, Marko Djordjevic
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Microbiology
Subjects:
CRISPR-Cas activation
pre-crRNA processing
CRISPR regulation
crRNA generation
biophysical modeling
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02139/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02139/full

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