Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

BackgroundAlpha 7 nicotinic acetylcholine receptor (α7nAChR) agonists have been developed to treat schizophrenia but failed in clinical trials due to rapid desensitization. GAT107, a type 2 allosteric agonist-positive allosteric modulator (ago-PAM) to the α7 nAChR was designed to activate the α7 nAC...

Full description

Bibliographic Details
Main Authors: Brittany M. Brems, Erin E. Sullivan, Jenna G. Connolly, Jingchun Zhang, Arnold Chang, Richard Ortiz, Lucas Cantwell, Praveen Kulkarni, Ganesh A. Thakur, Craig F. Ferris
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neuroscience
Subjects:
somatosensory cortex
schizophrenia
resting state functional connectivity
basal ganglia
pain
corticothalamic neural circuitry
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1196786/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1196786/full

Similar Items