KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway

KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway

Here, we investigated the detailed molecular oncogenic mechanisms of a novel receptor tyrosine kinase (RTK) fusion, <i>KLC1-ROS1</i>, with an adapter molecule, KLC1, and an RTK, ROS1, discovered in pediatric glioma, and we explored a novel therapeutic target for glioma that possesses onc...

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Bibliographic Details
Main Authors: Takashi Fujii, Yoshiko Nakano, Daichi Hagita, Nobuyuki Onishi, Arumu Endo, Masaya Nakagawa, Toru Yoshiura, Yohei Otsuka, Satoru Takeuchi, Mario Suzuki, Yuzaburo Shimizu, Terushige Toyooka, Yuko Matsushita, Yuko Hibiya, Satoshi Tomura, Akihide Kondo, Kojiro Wada, Koichi Ichimura, Arata Tomiyama
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
glioma
oncogene
KLC1-ROS1 fusion
JAK-STAT pathway
Online Access:https://www.mdpi.com/2072-6694/16/1/9

Internet

https://www.mdpi.com/2072-6694/16/1/9

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