Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast

Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast

In Saccharomyces cerevisiae, Ras (RAt Sarcoma) activity plays a central role in mediating the effect of glucose in decreasing stress resistance and longevity, with constitutive Ras activation mutations promoting cell growth and oncogenesis. Here, we used transposon mutagenesis in yeast to identify s...

Full description

Bibliographic Details
Main Authors: M.G. Mirisola, V.D. Longo
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedical Journal
Subjects:
Aging
Ras activity modulators
Phosphoinositides
Ras Pathway
Transposon mutagenesis
Ras suppressors
Online Access:http://www.sciencedirect.com/science/article/pii/S2319417023001312

Internet

http://www.sciencedirect.com/science/article/pii/S2319417023001312

Similar Items