Extract of Mallotus oppositifolius (Geiseler) Müll. Arg. increased prefrontal cortex dendritic spine density and serotonin and attenuated para-chlorophenylalanine-aggravated aggressive and depressive behaviors in mice

Extract of Mallotus oppositifolius (Geiseler) Müll. Arg. increased prefrontal cortex dendritic spine density and serotonin and attenuated para-chlorophenylalanine-aggravated aggressive and depressive behaviors in mice

Background/Aim: Depression-related aggression is linked to serotonin (5-HT) and dendritic spine alterations. Although Mallotus oppositifolius extract (MOE) has potential for reducing this effect, its specific role remains uncertain. Herein, we evaluated this potential and associated alterations in t...

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Bibliographic Details
Main Authors: Kennedy K.E. Kukuia, Frimpong Appiah, George J. Dugbartey, Yaw F. Takyi, Patrick Amoateng, Seth K. Amponsah, Ofosua Adi-Dako, Awo E. Koomson, Frederick Ayertey, Kevin K. Adutwum-Ofosu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
Mallotus oppositifolius
serotoninergic system
pCPA-induced aggression
resident-intruder
dendritic spine density
prefrontal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.962549/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.962549/full

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