Extract of Mallotus oppositifolius (Geiseler) Müll. Arg. increased prefrontal cortex dendritic spine density and serotonin and attenuated para-chlorophenylalanine-aggravated aggressive and depressive behaviors in mice
Background/Aim: Depression-related aggression is linked to serotonin (5-HT) and dendritic spine alterations. Although Mallotus oppositifolius extract (MOE) has potential for reducing this effect, its specific role remains uncertain. Herein, we evaluated this potential and associated alterations in t...
Main Authors: | Kennedy K.E. Kukuia, Frimpong Appiah, George J. Dugbartey, Yaw F. Takyi, Patrick Amoateng, Seth K. Amponsah, Ofosua Adi-Dako, Awo E. Koomson, Frederick Ayertey, Kevin K. Adutwum-Ofosu |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-10-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.962549/full |
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