LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

Notch signaling primarily determines T-cell fate. However, the molecular mechanisms underlying the maintenance of T-lineage potential in pre-thymic progenitors remain unclear. Here, we established two murine Ebf1-deficient pro-B cell lines, with and without T-lineage potential. The latter expressed...

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Bibliographic Details
Main Authors: Ken-ichi Hirano, Hiroyuki Hosokawa, Maria Koizumi, Yusuke Endo, Takashi Yahata, Kiyoshi Ando, Katsuto Hozumi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
Lmo2
Notch signaling
Tcf7
T-cell lineage
Online Access:https://elifesciences.org/articles/68227

Internet

https://elifesciences.org/articles/68227

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