Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction

Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction

Abstract Background A pro-oxidant enzyme, NADPH oxidase 4 (Nox4) has been reported to be a critical downstream effector of TGFβ-induced myofibroblast transformation during fibrosis. While there are a small number of studies suggesting an oncogenic role of Nox4 derived from activated fibroblasts, dir...

Full description

Bibliographic Details
Main Authors: Shakeel Mir, Briana D. Ormsbee Golden, Brandon J. Griess, Raghupathy Vengoji, Eric Tom, Elizabeth A. Kosmacek, Rebecca E. Oberley-Deegan, Geoffrey A. Talmon, Vimla Band, Melissa LT. Teoh-Fitzgerald
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Breast Cancer Research
Subjects:
Cancer-associated fibroblasts
NADPH Oxidase 4
Pro-oxidant
Autophagy
Adaptive stress response pathway
Nuclear factor-erythroid factor 2-related factor 2
Online Access:https://doi.org/10.1186/s13058-022-01548-6

Internet

https://doi.org/10.1186/s13058-022-01548-6

Similar Items