Pharmacokinetics and Drug-Drug Interactions of Abacavir and Lamuvudine Co-administered With Antituberculosis Drugs in HIV-Positive Children Treated for Multidrug-Resistant Tuberculosis

Pharmacokinetics and Drug-Drug Interactions of Abacavir and Lamuvudine Co-administered With Antituberculosis Drugs in HIV-Positive Children Treated for Multidrug-Resistant Tuberculosis

Given the high prevalence of multidrug-resistant (MDR)-TB in high HIV burden settings, it is important to identify potential drug-drug interactions between MDR-TB treatment and widely used nucleoside reverse transcriptase inhibitors (NRTIs) in HIV-positive children. Population pharmacokinetic models...

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Bibliographic Details
Main Authors: Louvina E. van der Laan, Anthony J. Garcia-Prats, H. Simon Schaaf, Jana L. Winckler, Heather Draper, Jennifer Norman, Lubbe Wiesner, Helen McIlleron, Paolo Denti, Anneke C. Hesseling
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
tuberculosis
paediatrics (drugs and medicines)
HIV
drug drug interactions
pharmacometric modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.722204/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.722204/full

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