Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction

Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction

Methionine sulfoxide reductase A (MsrA) is a widely expressed antioxidant enzyme that counteracts oxidative protein damage and contributes to protein regulation by reversing oxidation of protein methionine residues. In retinal pigment epithelial (RPE) cells in culture, MsrA overexpression increases...

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Bibliographic Details
Main Authors: Francesca Mazzoni, Ying Dun, Jade A. Vargas, Emeline F. Nandrot, Silvia C. Finnemann
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Redox Biology
Subjects:
MsrA
Oxidative stress
Phagocytosis
Photoreceptors
Retina
Retinal pigment epithelium
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000665

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http://www.sciencedirect.com/science/article/pii/S2213231721000665

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