Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery

Abstract Background Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of the CGRP-receptor antagonist telcagepant on intracellular Ca2+ -levels an...

Full description

Bibliographic Details
Main Authors: André Erdling, Majid Sheykhzade, Lars Edvinsson
Format: Article
Language:English
Published: BMC 2017-05-01
Series:The Journal of Headache and Pain
Subjects:
CGRP
Calcitonin gene related peptide
Telcagepant
Pressurized arteriography
FURA-2
Middle cerebral artery
Online Access:http://link.springer.com/article/10.1186/s10194-017-0768-4

Internet

http://link.springer.com/article/10.1186/s10194-017-0768-4

Similar Items