Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling

Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling

K-ras mutations are major genetic events that drive cancer development associated with aggressive malignant phenotypes, while expression of the immune checkpoint molecule PD-L1 plays a key role in cancer evasion of the immune surveillance that also profoundly affects the patient outcome. However, th...

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Bibliographic Details
Main Authors: Christophe Glorieux, Xiaojun Xia, Yong-Qiao He, Yumin Hu, Kelly Cremer, Annie Robert, Junchen Liu, Fen Wang, Jianhua Ling, Paul J. Chiao, Peng Huang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
PD-L1
K-ras
ROS
FGFR1
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172030985X

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http://www.sciencedirect.com/science/article/pii/S221323172030985X

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