Exercise Modifies the Transcriptional Regulatory Features of Monocytes in Alzheimer’s Patients: A Multi-Omics Integration Analysis Based on Single Cell Technology

Exercise Modifies the Transcriptional Regulatory Features of Monocytes in Alzheimer’s Patients: A Multi-Omics Integration Analysis Based on Single Cell Technology

Monocytes have been reported to be important mediators of the protective effect of exercise against the development of Alzheimer’s disease (AD). This study aims explored the mechanism by which monocytes achieve this. Using single cell transcriptome analysis, results showed that CD14 + and CD16 + mon...

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Bibliographic Details
Main Authors: Yisheng Chen, Yaying Sun, Zhiwen Luo, Xiangjun Chen, Yi Wang, Beijie Qi, Jinrong Lin, Wei-Wei Lin, Chenyu Sun, Yifan Zhou, Jiebin Huang, Yuzhen Xu, Jiwu Chen, Shiyi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
exercise
monocyte
transcription factors
cell communication
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.881488/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.881488/full

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