Comprehensive Analysis of SWI/SNF Inactivation in Lung Adenocarcinoma Cell Models

Comprehensive Analysis of SWI/SNF Inactivation in Lung Adenocarcinoma Cell Models

Mammalian SWI/SNF (SWitch/Sucrose Non-Fermentable) complexes are ATP-dependent chromatin remodelers whose subunits have emerged among the most frequently mutated genes in cancer. Studying SWI/SNF function in cancer cell line models has unveiled vulnerabilities in SWI/SNF-mutant tumors that can lead...

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Bibliographic Details
Main Authors: Paola Peinado, Alvaro Andrades, Marta Cuadros, Maria Isabel Rodriguez, Isabel F. Coira, Daniel J. Garcia, Juan Carlos Álvarez-Perez, Carlos Baliñas-Gavira, Alberto M. Arenas, Juan Rodrigo Patiño-Mercau, Juan Sanjuan-Hidalgo, Octavio A. Romero, Luis M. Montuenga, Julian Carretero, Montserrat Sanchez-Cespedes, Pedro P. Medina
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
SWI/SNF complex
lung cancer
lung adenocarcinoma
epigenetics
cell models
multi-omics
Online Access:https://www.mdpi.com/2072-6694/12/12/3712

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https://www.mdpi.com/2072-6694/12/12/3712

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