Transporter-Mediated Drug Interaction Strategy for 5-Aminolevulinic Acid (ALA)-Based Photodynamic Diagnosis of Malignant Brain Tumor: Molecular Design of ABCG2 Inhibitors

Transporter-Mediated Drug Interaction Strategy for 5-Aminolevulinic Acid (ALA)-Based Photodynamic Diagnosis of Malignant Brain Tumor: Molecular Design of ABCG2 Inhibitors

Photodynamic diagnosis (PDD) is a practical tool currently used in surgical operation of aggressive brain tumors, such as glioblastoma. PDD is achieved by a photon-induced physicochemical reaction which is induced by excitation of protoporphyrin IX (PpIX) exposed to light. Fluorescence-guided gross-...

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Bibliographic Details
Main Authors: Toshihisa Ishikawa, Shin-ichi Miyatake, Toshihiko Kuroiwa, Shun-ichiro Ogura, Yuichiro Hagiya, Yoshinaga Kajimoto, Naokado Ikeda, Kenkichi Takahashi
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Pharmaceutics
Subjects:
brain tumor
glioma
photodynamic diagnosis
5-aminolevulinic acid (ALA)
ABC transporter
ABCG2
protein kinase inhibitor
Online Access:http://www.mdpi.com/1999-4923/3/3/615/

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http://www.mdpi.com/1999-4923/3/3/615/

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