Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay

Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay

Abstract Background The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort and the lack of universal detection kit, thus the clinical implication remains disputed. Methods A broad-spectrum peptide...

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Bibliographic Details
Main Authors: Yandan Wu, Xiaotao Liu, Yuan Mao, Ruixue Ji, Lingzhi Xia, Zining Zhou, Yan Ding, Pinqing Li, Yu Zhao, Min Peng, Jie Qiu, Chuanlai Shen
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
Chronic hepatitis B
Antigen-specific T cell
T-cell epitopes
ELISpot
Online Access:https://doi.org/10.1186/s12967-024-05062-5

Internet

https://doi.org/10.1186/s12967-024-05062-5

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