A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression

A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression

Dihydroorotate dehydrogenase (DHODH)-mediated ferroptosis defense is a targetable vulnerability in cancer. Currently, only a few DHODH inhibitors have been utilized in clinical practice. To further enhance DHODH targeting, we introduced the mitochondrial targeting group triphenylphosphine (TPP) to b...

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Bibliographic Details
Main Authors: Yongrui Hai, Renming Fan, Ting Zhao, Ruizhuo Lin, Junyan Zhuang, Aohua Deng, Shanshui Meng, Zhuang Hou, Gaofei Wei
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Pharmacological Research
Subjects:
DHODH inhibitor
Mitochondrial-targeting
Ferroptosis
Anticancer
Melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824000598

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http://www.sciencedirect.com/science/article/pii/S1043661824000598

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