In silico validation revealed the role of SCN5A mutations and their genotype–phenotype correlations in Brugada syndrome

In silico validation revealed the role of SCN5A mutations and their genotype–phenotype correlations in Brugada syndrome

Abstract Background Brugada syndrome (BrS) is a rare genetic disease that causes sudden cardiac death (SCD) and arrhythmia. SCN5A pathogenic variants (about 30% of diagnosed patients) are responsible for BrS. Aims Lack of knowledge regarding molecular characteristics and the correlation between geno...

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Main Authors: Hung Manh Pham, Duy Phuong Nguyen, Thanh Dat Ta, Thi Phuong Le, Phong Hai Phan, Hoai An Trinh, Tuan Viet Tran, Thi Lan Anh Luong, Ha Minh Nguyen, The‐Hung Bui, Thinh Huy Tran, Thanh Van Ta, Van‐Khanh Tran
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
Brugada syndrome
genotype–phenotype correlation
in silico
SCN5A mutations
Online Access:https://doi.org/10.1002/mgg3.2263

Internet

https://doi.org/10.1002/mgg3.2263

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