GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer

GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer

BACKGROUND: Knowledge of factors and mechanisms contributing to the inherent radioresistance of pancreatic cancer may improve cancer treatment. Irradiation inhibits glycogen synthase kinase 3β (GSK3β) by phosphorylation at serine 9. In turn, release of cytosolic membrane β-catenin with subsequent nu...

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Bibliographic Details
Main Authors: Richard L. Watson, Aaron C. Spalding, Steven P. Zielske, Meredith Morgan, Alex C. Kim, Guido T. Bommer, Hagit Eldar-Finkelman, Thomas Giordano, Eric R. Fearon, Gary D. Hammer, Theodore S. Lawrence, Edgar Ben-Josef
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800533

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http://www.sciencedirect.com/science/article/pii/S1476558610800533

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