Menthol- and thymol-based ciprofloxacin derivatives against Mycobacterium tuberculosis: in vitro activity, lipophilicity, and computational studies

Menthol- and thymol-based ciprofloxacin derivatives against Mycobacterium tuberculosis: in vitro activity, lipophilicity, and computational studies

Abstract In this work, we investigated the antitubercular properties of Ciprofloxacin derivatives conjugated with menthol and thymol moieties. For the sixteen derivatives, we established minimal inhibitory concentrations (MIC) using isolates of Mycobacterium tuberculosis that were resistant or susce...

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Hlavní autoři: Daniel Szulczyk, Mateusz Woziński, Michał Koliński, Sebastian Kmiecik, Agnieszka Głogowska, Ewa Augustynowicz-Kopeć, Michał A. Dobrowolski, Piotr Roszkowski, Marta Struga, Krzesimir Ciura
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2023-09-01
Edice:Scientific Reports
On-line přístup:https://doi.org/10.1038/s41598-023-43708-4

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