A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution
To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated. Among the oils and surfactants studied, Imwitor® 742, Tween® 60, Cremophore® EL and Transcutol® HP were selected as they showed maximal sol...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-04-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087614000968 |
| _version_ | 1829482609478991872 |
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| author | Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang |
| author_facet | Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang |
| author_sort | Pornsak Sriamornsak |
| collection | DOAJ |
| description | To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated. Among the oils and surfactants studied, Imwitor® 742, Tween® 60, Cremophore® EL and Transcutol® HP were selected as they showed maximal solubility to mefenamic acid. The ternary phase diagram was constructed to find optimal concentration that provided the highest drug loading. The droplet size after dispersion and drug dissolution of selected formulations were investigated. The results showed that the formulation containing Imwitor® 742, Tween® 60 and Transcutol® HP (10:30:60) can encapsulate high amount of mefenamic acid. The dissolution study demonstrated that, in the medium containing surfactant, nearly 100% of mefenamic acid were dissolved from SEF within 5 min while 80% of drugs were dissolved from the commercial product in 45 min. In phosphate buffer (without surfactant), 80% of drug were dissolved from the developed SEF within 5 min while only about 13% of drug were dissolved in 45 min, from the commercial product. The results suggested that the SEF can enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug. |
| first_indexed | 2024-12-14T21:51:02Z |
| format | Article |
| id | doaj.art-0f19226909cb4f6492023501dea465ca |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-14T21:51:02Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-0f19226909cb4f6492023501dea465ca2022-12-21T22:46:15ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762015-04-0110212112710.1016/j.ajps.2014.10.003A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolutionPornsak Sriamornsak0Sontaya Limmatvapirat1Suchada Piriyaprasarth2Punyanutch Mansukmanee3Zongkang Huang4Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandTo enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated. Among the oils and surfactants studied, Imwitor® 742, Tween® 60, Cremophore® EL and Transcutol® HP were selected as they showed maximal solubility to mefenamic acid. The ternary phase diagram was constructed to find optimal concentration that provided the highest drug loading. The droplet size after dispersion and drug dissolution of selected formulations were investigated. The results showed that the formulation containing Imwitor® 742, Tween® 60 and Transcutol® HP (10:30:60) can encapsulate high amount of mefenamic acid. The dissolution study demonstrated that, in the medium containing surfactant, nearly 100% of mefenamic acid were dissolved from SEF within 5 min while 80% of drugs were dissolved from the commercial product in 45 min. In phosphate buffer (without surfactant), 80% of drug were dissolved from the developed SEF within 5 min while only about 13% of drug were dissolved in 45 min, from the commercial product. The results suggested that the SEF can enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug.http://www.sciencedirect.com/science/article/pii/S1818087614000968Self-emulsifying formulationPoorly water-soluble drugMefenamic acidDrug dissolution |
| spellingShingle | Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution Asian Journal of Pharmaceutical Sciences Self-emulsifying formulation Poorly water-soluble drug Mefenamic acid Drug dissolution |
| title | A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution |
| title_full | A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution |
| title_fullStr | A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution |
| title_full_unstemmed | A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution |
| title_short | A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution |
| title_sort | new self emulsifying formulation of mefenamic acid with enhanced drug dissolution |
| topic | Self-emulsifying formulation Poorly water-soluble drug Mefenamic acid Drug dissolution |
| url | http://www.sciencedirect.com/science/article/pii/S1818087614000968 |
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