Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's diseaseResearch in context

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's diseaseResearch in context

Summary: Background: In Huntington's disease (HD), a CAG repeat expansion mutation in the Huntingtin (HTT) gene drives a gain-of-function toxicity that disrupts mRNA processing. Although dysregulation of gene splicing has been shown in human HD post-mortem brain tissue, post-mortem analyses ar...

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Bibliographic Details
Main Authors: Vincent Tano, Kagistia Hana Utami, Nur Amirah Binte Mohammad Yusof, Jocelyn Bégin, Willy Wei Li Tan, Mahmoud A. Pouladi, Sarah R. Langley
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:EBioMedicine
Subjects:
Huntington's disease
Alternative splicing
mRNA processing
Neurodegenerative disease
High-throughput RNA-sequencing
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423002852

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http://www.sciencedirect.com/science/article/pii/S2352396423002852

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