Monomeric CRP regulates inflammatory responses in human intervertebral disc cells

Monomeric CRP regulates inflammatory responses in human intervertebral disc cells

Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined. CRP in its pentameric form exhibits weak anti-inflammatory activity. The monomeric isofor...

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Bibliographic Details
Main Authors: Clara Ruiz-Fernández, Djedjiga Ait Eldjoudi, Maria González-Rodríguez, Alfonso Cordero Barreal, Yousof Farrag, Lucia García-Caballero, Francisca Lago, Ali Mobasheri, Daisuke Sakai, Jesús Pino, Oreste Gualillo
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-03-01
Series:Bone & Joint Research
Subjects:
monomeric crp
inflammation
intervertebral disc
annulus fibrosus
nucleus pulposus
low back pain
crp
intervertebral disc (ivd)
matrix metalloproteinase 13
interleukin
quantitative real-time polymerase chain reaction
mrna
western blot
annulus fibrosus (af) tissue
il-8
rna
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.123.BJR-2022-0223.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.123.BJR-2022-0223.R1

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