A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice

A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid droplets (LDs) within hepatocytes. Perilipin 2 (PLIN2) is the most abundant protein in hepatic LDs and its expression correlates with intracellular lipid accumulation. A recently discov...

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Bibliographic Details
Main Authors: Eleonora Scorletti, Yedidya Saiman, Sookyoung Jeon, Carolin V. Schneider, Delfin G. Buyco, Chelsea Lin, Blanca E. Himes, Clementina A. Mesaros, Marijana Vujkovic, Kate Townsend Creasy, Emma E. Furth, Jeffrey T. Billheimer, Nicholas J. Hand, David E. Kaplan, Kyong-Mi Chang, Philip S. Tsao, Julie A. Lynch, Joseph L. Dempsey, Julia Harkin, Susovon Bayen, Donna Conlon, Marie Guerraty, Michael C. Phillips, Daniel J. Rader, Rotonya M. Carr
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:JHEP Reports
Subjects:
NAFLD
Lipid droplets
Perilipin
DGAT2
triglycerides
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002331

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http://www.sciencedirect.com/science/article/pii/S2589555923002331

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