A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway.

A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway.

<h4>Background</h4>Gut epithelium is the first natural barrier against Trichinella spiralis larval invasion, but the mechanism by which larval penetration of gut epithelium is not completely elucidated. Previous studies showed that proteases secreted by T. spiralis intestinal infective l...

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Bibliographic Details
Main Authors: Yan Yan Song, Xin Zhuo Zhang, Bo Ning Wang, Yong Kang Cheng, Xin Guo, Xi Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011872&type=printable

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https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011872&type=printable

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