Activity and rational combinations of a novel, engineered chimeric, TRAIL-based ligand in diffuse large B-cell lymphoma

Activity and rational combinations of a novel, engineered chimeric, TRAIL-based ligand in diffuse large B-cell lymphoma

BackgroundTRAIL (TNF-related apoptosis inducing ligand) exhibits selective proapoptotic activity in multiple tumor types, while sparing normal cells. This selectivity makes TRAIL an attractive therapeutic candidate. However, despite encouraging activity in preclinical models, clinical trials with TR...

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Bibliographic Details
Main Authors: Karolina Piechna, Aleksandra Żołyniak, Ewa Jabłońska, Monika Noyszewska-Kania, Maciej Szydłowski, Bartłomiej Żerek, Maria Kulecka, Izabela Rumieńczyk, Michał Mikula, Przemysław Juszczyński
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
TRAIL
apoptosis
DLBCL
venetoclax
drug resistance
endocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1048741/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1048741/full

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