One-Pot Multicomponent Synthesis of Methoxybenzo[<i>h</i>]quinoline-3-carbonitrile Derivatives; Anti-Chagas, X-ray, and In Silico ADME/Tox Profiling Studies

One-Pot Multicomponent Synthesis of Methoxybenzo[<i>h</i>]quinoline-3-carbonitrile Derivatives; Anti-Chagas, X-ray, and In Silico ADME/Tox Profiling Studies

Several methoxybenzo[<i>h</i>]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioning approach to developing compounds with anti-prostate cancer and anti-Chagas disease properties. The compounds were synthesized through a sequential multicomponent reaction of ar...

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Bibliographic Details
Main Authors: Hegira Ramírez, Katiuska Charris, Esteban Fernandez-Moreira, Benjamín Nogueda-Torres, Mario V. Capparelli, Jorge Ángel, Jaime Charris
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
cancer
chagas
one-pot synthesis
methoxybenzo[<i>h</i>]quinoline
Online Access:https://www.mdpi.com/1420-3049/26/22/6977

Internet

https://www.mdpi.com/1420-3049/26/22/6977

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