PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

Abstract Background CD8+ T cells differentiate into exhausted status within tumors, including hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor immunity. A detailed characterization of exhausted T cells and their prognostic value in HCC is lacking. Methods We...

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Bibliographic Details
Main Authors: Jiaqiang Ma, Bohao Zheng, Shyamal Goswami, Lu Meng, Dandan Zhang, Chunmei Cao, Teng Li, Fangming Zhu, Lijie Ma, Zhao Zhang, Shuhao Zhang, Meng Duan, Qin Chen, Qiang Gao, Xiaoming Zhang
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Hepatocellular carcinoma
CD8+ T cells
T cell exhaustion
Multiplex immunohistochemistry
Spatial analysis
Online Access:http://link.springer.com/article/10.1186/s40425-019-0814-7

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http://link.springer.com/article/10.1186/s40425-019-0814-7

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