The immune landscape of undifferentiated pleomorphic sarcoma

The immune landscape of undifferentiated pleomorphic sarcoma

IntroductionUndifferentiated pleomorphic sarcoma (UPS) can be associated with a relatively dense immune infiltration. Immune checkpoint inhibitors (anti-PD1, anti-PDL1, and anti-CTLA4) are effective in 20% of UPS patients. We characterize the immune microenvironment of UPS and its association with o...

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Main Authors: Rossana Lazcano, Carmelia M. Barreto, Ruth Salazar, Fernando Carapeto, Raymond S. Traweek, Cheuk H. Leung, Swati Gite, Jay Mehta, Davis R. Ingram, Khalida M. Wani, Kim-Anh T. Vu, Edwin R. Parra, Wei Lu, Jianling Zhou, Russell G. Witt, Brandon Cope, Prapassorn Thirasastr, Heather Y. Lin, Christopher P. Scally, Anthony P. Conley, Ravin Ratan, J. Andrew Livingston, Alexandra M. Zarzour, Joseph Ludwig, Dejka Araujo, Vinod Ravi, Shreyaskumar Patel, Robert Benjamin, Jennifer Wargo, Ignacio I. Wistuba, Neeta Somaiah, Christina L. Roland, Emily Z. Keung, Luisa Solis, Wei-Lien Wang, Alexander J. Lazar, Elise F. Nassif
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
undifferentiated pleomorphic sarcoma
immune checkpoint inhibitors
adenosine pathway
immune microenvironment
tertiary lymphoid structures
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1008484/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1008484/full

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