A Novel High-Mannose Specific Lectin from the Green Alga Halimeda renschii Exhibits a Potent Anti-Influenza Virus Activity through High-Affinity Binding to the Viral Hemagglutinin

A Novel High-Mannose Specific Lectin from the Green Alga Halimeda renschii Exhibits a Potent Anti-Influenza Virus Activity through High-Affinity Binding to the Viral Hemagglutinin

We have isolated a novel lectin, named HRL40 from the green alga Halimeda renschii. In hemagglutination-inhibition test and oligosaccharide-binding experiment with 29 pyridylaminated oligosaccharides, HRL40 exhibited a strict binding specificity for high-mannose N-glycans having an exposed (α1-3) ma...

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Bibliographic Details
Main Authors: Jinmin Mu, Makoto Hirayama, Yuichiro Sato, Kinjiro Morimoto, Kanji Hori
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Marine Drugs
Subjects:
lectin
green alga
Halimeda renschii
high-mannose specificity
anti-influenza virus activity
Online Access:https://www.mdpi.com/1660-3397/15/8/255

Internet

https://www.mdpi.com/1660-3397/15/8/255

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