Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis

Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis

BackgroundDuring liver injury, liver sinusoidal endothelial cells (LSECs) dysfunction and capillarization promote liver fibrosis. We have previously reported that the LSEC vascular cell adhesion molecule 1 (VCAM1) plays a key role in liver inflammation in nonalcoholic steatohepatitis (NASH) and we n...

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Bibliographic Details
Main Authors: Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. Tschumperlin, Petra Hirsova, Samar H. Ibrahim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
fibrosis
inflammation
liver sinusoidal endothelial cells (LSECs)
hepatic stellate cells (HSCs)
nonalcoholic steatohepatitis - NASH
vascular cell adhesion molecule 1 (VCAM1)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.983255/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.983255/full

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