Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis

Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis

BackgroundDuring liver injury, liver sinusoidal endothelial cells (LSECs) dysfunction and capillarization promote liver fibrosis. We have previously reported that the LSEC vascular cell adhesion molecule 1 (VCAM1) plays a key role in liver inflammation in nonalcoholic steatohepatitis (NASH) and we n...

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Bibliographic Details
Main Authors:	Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. Tschumperlin, Petra Hirsova, Samar H. Ibrahim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Immunology
Subjects:	fibrosis inflammation liver sinusoidal endothelial cells (LSECs) hepatic stellate cells (HSCs) nonalcoholic steatohepatitis - NASH vascular cell adhesion molecule 1 (VCAM1)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.983255/full

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