Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone

Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone

Renal fibrosis is the inevitable pathway of the progression of chronic kidney disease to end-stage renal disease, which manifests as progressive glomerulosclerosis and renal interstitial fibrosis. In a previous study, we observed severe interstitial fibrosis in the contralateral kidneys of 6-month u...

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Bibliographic Details
Main Authors: Panpan Qiang, Juan Hao, Fan Yang, Yutong Han, Yi Chang, Yunqian Xian, Yunzhao Xiong, Xiaomeng Gao, Lijuan Liang, Tatsuo Shimosawa, Qingyou Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Renal fibrosis
aldosterone
mineralocorticoid receptor blocker
macrophage-to-myofibroblast transition (MMT)
M1/M2 macrophage
TGF-β1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.948658/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.948658/full

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