Sirtuin 3 Dependent and Independent Effects of NAD<sup>+</sup> to Suppress Vascular Inflammation and Improve Endothelial Function in Mice

Sirtuin 3 Dependent and Independent Effects of NAD<sup>+</sup> to Suppress Vascular Inflammation and Improve Endothelial Function in Mice

Atherosclerosis is initiated by endothelial cell dysfunction and vascular inflammation under the condition of hyperlipidemia. Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent mitochondrial deacetylase, which plays a key role in maintaining normal mitoc...

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Bibliographic Details
Main Authors: Xiaoyun Cao, Yalan Wu, Huiling Hong, Xiao Yu Tian
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antioxidants
Subjects:
atherosclerosis
vascular inflammation
endothelial dysfunction
mitochondrial ROS
sirtuins
Online Access:https://www.mdpi.com/2076-3921/11/4/706

Internet

https://www.mdpi.com/2076-3921/11/4/706

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