Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD

IntroductionEarly recovery of donor-derived invariant natural killer T (iNKT) cells are associated with reduced risk of graft-versus-host disease (GvHD) and overall survival. Patients with severe GvHD, however, had much slower iNKT cell reconstitution relative to conventional T cells.MethodsTo chara...

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Bibliographic Details
Main Authors: Weijia Zhao, Yujia Wang, Xinwei Zhang, Jie Hao, Kunshan Zhang, Xiaojun Huang, Yingjun Chang, Hounan Wu, Rong Jin, Qing Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
invariant natural killer T cells
haploidentical bone marrow transplantation
thymus
NKT1 precursor
graft-versus host disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203614/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203614/full

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