Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD

IntroductionEarly recovery of donor-derived invariant natural killer T (iNKT) cells are associated with reduced risk of graft-versus-host disease (GvHD) and overall survival. Patients with severe GvHD, however, had much slower iNKT cell reconstitution relative to conventional T cells.MethodsTo chara...

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Detalhes bibliográficos
Principais autores: Weijia Zhao, Yujia Wang, Xinwei Zhang, Jie Hao, Kunshan Zhang, Xiaojun Huang, Yingjun Chang, Hounan Wu, Rong Jin, Qing Ge
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2023-08-01
coleção:Frontiers in Immunology
Assuntos:
invariant natural killer T cells
haploidentical bone marrow transplantation
thymus
NKT1 precursor
graft-versus host disease
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203614/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203614/full

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