Antibodies Against Pseudomonas aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme

Antibodies Against Pseudomonas aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme

Extracellular traps released by neutrophils (NETs) are essential for the clearance of Pseudomonas aeruginosa. Alkaline protease (AprA) secreted by P. aeruginosa negatively correlates with clinical improvement. Moreover, anti-AprA in patients with cystic fibrosis (CF) can help identify patients with...

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Bibliographic Details
Main Authors: Chendi Jing, Chenghua Liu, Yu Liu, Ruli Feng, Run Cao, Zhangchun Guan, Bo Xuan, Yaping Gao, Qi Wang, Nana Yang, Yuanfang Ma, Lefu Lan, Jiannan Feng, Beifen Shen, Hui Wang, Yanyan Yu, Guang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
Pseudomonas aeruginosa
alkaline protease
alkaline protease inhibitor
neutrophil extracellular traps
antibody-dependent enhancement
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.654649/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.654649/full

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