RNA/aTNA Chimeras: RNAi Effects and Nucleases Resistance of Single and Double Stranded RNAs

RNA/aTNA Chimeras: RNAi Effects and Nucleases Resistance of Single and Double Stranded RNAs

The RNA interference pathway (RNAi) is a specific and powerful biological process, triggered by small non-coding RNA molecules and involved in gene expression regulation. In this work, we explored the possibility of increasing the biological stability of these RNA molecules by replacing their natura...

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Bibliographic Details
Main Authors: Adele Alagia, Montserrat Terrazas, Ramon Eritja
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
RNAi
siRNA
3′-overhang chemical modification
single-stranded siRNA
L-threoninol
3′-exonuclease
5′-exonuclease
serum resistance
ApoB gene
Online Access:http://www.mdpi.com/1420-3049/19/11/17872

Internet

http://www.mdpi.com/1420-3049/19/11/17872

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