Collateral Sensitivity Interactions between Antibiotics Depend on Local Abiotic Conditions

ABSTRACT Mutations conferring resistance to one antibiotic can increase (cross-resistance) or decrease (collateral sensitivity) resistance to others. Antibiotic combinations displaying collateral sensitivity could be used in treatments that slow resistance evolution. However, lab-to-clinic translati...

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Bibliographic Details
Main Authors: Richard C. Allen, Katia R. Pfrunder-Cardozo, Alex R. Hall
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:mSystems
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mSystems.01055-21